Immune Privilege Furnishes a Niche for Latent Infection

The microenvironment of the CNS (eye and brain) is fertile ground for infection if barriers are breached. result pathogen invasion often devastating destruction tissues. In eye, inflammation broadly classified either as “infectious” (i.e. caused by infection) or “non-infectious”. However, increasingly, forms intraocular (IOI), which clinically appear to be “non-infectious” turn out initiated infectious agents, suggesting that pathogens have been retained in latent persistent form within ocular tissues reactivated cause overt disease. A similar pathogenesis applies infections brain. Not all provide an equally protective niche while different escape detection using strategies. This review summarises how immune privilege (IP) may permissive allow eye brain act a reservoir remain undetected lifetime host but states deficiency activated sight- life-threatening inflammation.